Post Cycle Therapy with Anti Estrogen and Aromatase Inhibitor Femara (Letrozole)

Letrozole is primarily used to ward off any estrogenic side effects caused by a cycle of anabolic steroids. Letrozole has been show to have the capability of reducing the level of estrogen in users' bodies by up to 96-98%.
 Letrozole is a non steroidal selective third generation aromatse inhibitor. The structure and activity of this compound are very similar to that of Arimidex, and is prescribed for similar medical reasons. More specifically, United States prescribing guidelines for Letrozole recommend it to be used for the treatment of postmenopausal women with estrogen receptor positive or estrogen receptor unknown brest cancer. It is typically used as a second line of treatment after an estrogen receptor antagonist like tamoxifen has failed to elicit a desirable response, although it is sometimes initiated as the first course of therapy depending on the circumstances. Male bodybuilders and athletes find value in Letrozole for its ability to mitigate the estrogenic side effects associated with the use of aromatically anabolic/androgenic steroids, such as gynecomastia, fat buildup, and visible water retention. The U.S. FDA approved Letrozole for prescription sale in 1997, where it is sold by  the pharmaceutical company Novartis under the brand name of Femera.

In terms of how this drug  can be used to the benefit of bodybuilders and strength athletes, Letrozole is primarily used to ward off any estrogenic side effects caused by the administration of anabolic steroids. Letrozole has been show to have the capability of reducing the level of estrogen in users' bodies by up to 96-98%. This would seemingly be enough in itself to make the compound a desirable one with which steroid users would be interested in. However Letrozole also has been shown to increase the amount of lutenizing hormone, follicle stimulating hormone, and sex hormone binding globulin in users. When you combine these attributes with the fact that it will help protect against gynecomastia, water retention and other estrogenic side effects Letrozole obviously can fulfill many users' needs.  There are some animal studies that have suggested that letrozole can help to reduce or even eliminate pre-existing gynecomastia as well. Of course there are some limits to this research as it has never been conducted using human subjects but it does demonstrate that there may be a mechanism by which this could occur. Anecdotally some users have reported that they have experienced a reduction in their own pre-existing gynecomastia, but of course these reports have their limits as they were not conducted with the scientific controls in place. Interestingly, it takes approximately 60 days to get a steady blood plasma level of Letrozole once administration of the drug begins. This may necessitate that a user begin using the compound prior to beginning their cycle if they wish for the effects to be at full strength once their cycle begins. This may also hinder the ability of the compound to respond quickly if a user begins administration of the drug to counteract some side effects that have appeared quickly.

The maximum dosage that a user would want to use would be 2.5mgs per day. It has been shown in numerous studies that this dosage will eliminate nearly all of the estrogen in the body in nearly all individuals. Any dose that is higher than this would simply be unneeded. Despite the ability to increase the amount of lutenizing hormone, follicle stimulating hormone, and sex hormone binding globulin in users Letrozole can be counterproductive if used during post-cycle therapy. This is due to the ability of the compound to drive estrogen levels too low during use. Once the compound is discontinued this can result in a "rebound effect" in estrogen levels with these becoming quite high, something that should be avoided during or after post-cycle therapy. Anastrozole could be seen as an alternative to Letrozole in this capacity as it seemingly does not have such a potent effect. The detrimental effect that Letrozole has on blood lipid levels is another reason why many will avoid it's use during post-cycle therapy.

The Benefits of Aromasin in bodybuilding

Aromasin is the trade name for Exemestane, a drug used to treat breast cancer in women. Similarly to arimidex, it is member of the aromatase inhibitor class of drugs. The drug was FDA approved in 1999 and has become very popular across the globe in post menopausal women. Aromasin is a suicidal aromatase inhibitor (AI), meaning it permanently disables the aromatase enzyme once it binds to it. In plain English, Aromasin will prevent the currently bound enzymes from rebounding, which is what separates this drug from Letrozole or Arimidex. When you use other AI’s, they temporarily stop estrogen from aromatizing, but when you stop taking them those same enzymes can rebound causing what is known as ‘estrogen rebound’. This explains why some anabolic steroid users experience gynecomastia (bitch tits) after cycle when using other AI’s. Studies on breast cancer patients have shown Aromasin reduced estrogen levels up to 85%. Certain anabolic androgenic steroids (AAS) convert to estrogen in the body; all testosterone esters, Nandrolones, dianabol, and Boldenone are examples. If not controlled, the user runs the risk of developing several types of estrogen side effects such as gynecomastia (bitch tits), water retention, blood pressure and heart problems. There is a domino effect that can occur if estrogen gets out of control.  Just imagine carrying around two gallons of water all day.

The user may notice feeling rundown and tired, blood pressure will soar, and motivation will decrease. These side effects will defeat the purpose of running steroids in the first place. In addition, high estrogen levels, when coming off a cycle, will interfere with recovery of the bodies natural testosterone levels.

On the other hand, if you run a harsh AI, which eliminates too much estrogen, it can also have negative effects on libido, mood, and dry out the joints. Since Aromasin is a suicide aromatase inhibitor, you should work on controlling the dosage and tailoring it to your cycle. Don’t just use random dosages without looking at your whole steroid cycle. Very similar in many ways to other aromatase inhibitors, particularly Arimidex and Letrozole, Aromasin has some characteristics unique unto its own. Like all aromatase inhibitors Aromasin is useful to the steroid using athlete in the prevention of unwanted side-effects such as Gynecomastia and excess water retention. By its mode of action Aromasin inhibits the conversion of estrogen in the body; as many anabolic steroids convert to estrogen after administration due to the aromatase process, Aromasin actively inhibits this process. By its inhibiting nature the total amount of estrogen in the body is reduced and blocked from binding thereby preventing common associated adverse side-effects. While the aromatase inhibiting effect is its primary function and primary reason for using Aromasin it also carries with it other characteristics that may be of interest to the anabolic steroid user. Aromasin has been shown to greatly stimulate natural testosterone production by a slight androgenic nature. While other aromatase inhibitors can also increase total testosterone production Aromasin actively does so while increasing natural IGF 1 production as well, Arimidex and Letrozole cannot boast such a claim.

For the anabolic androgenic steroid using athlete the most important question is when is the best time to use Aromasin as it can be effectively used while on cycle for the prevention of estrogenic related side-effects as well as during post cycle therapy (PCT.) It can be used for both purposes but most will find PCT periods to be best served with SERMs and hCG and the use of aromatase inhibitors while on cycle to be the most efficient method of practice. If you are on the verge of using Aromasin immediately or after your anabolic steroid cycle, it is critical that you have good knowledge of the benefits of the drug, tips while using this drug and also the precautions you need to take while using this drug.

Aromasin has an active life of about 24-40 hours. It has been used by athletes and bodybuilders both as an aromatose inhibitor on those harsh, aromatizable steroids. Aromasin works by inhibiting the production of estrogen in the body and initiating a restoration of natural hormone production. Aromasin is also potent enough to facilitate reversal of estrogen-induced negative reactions such as acne, oily skin and bloating within 3-5 weeks of usage. Aromasins also have the capability to greatly enhance the bioavailability of the anabolic steroids being used in the steroid cycles. Aromasin use in Post cycle therapy

As discussed Aromasin is an aromatose inhibtor which can reduce estrogen levels dramatically and enhance testosterone production. Aromasin however is not the most popular aromatose inhibitor in the market today as bodybuilders and athletes continue to prefer Arimidex and Letrozole over it. The reason is simple really, Aromasins came into the market much after the Arimidex or Letrozole so it has yet to receive the cult following the other two drugs command. Aromasin was introduced by a company called Pharmacia and Upjohn in the year 1999. Moreover, aromasins are not as widely availabe as Arimidex or Letrozole.  When there are the other  well accepted aromatose inhibitors in the market why should you consider Aromasin as your aromatose inhibitor of choice?  Letrozole and Arimidex can reduce estrogen levels up to 98% in the body which is more effective than the 85% of Aromasin. But a 98% reduction of estrogen can have complications for the user such as hindered muscle gain and a decrease in sex drive. Aromasin when taken in controlled dosages of 25mg per day leaves a sufficient amount of estrogen in the body and also promotes free development of insulin and testosterone in the body. Combining Aromasin with Nolvadex during post steroidal cycle therapy is potentially a better combination because of aromasin's capability of facilitating testosterone production which is considered vital in the post cycle therapy process.

Nolvadex is also known to greatly diminish the blood plasma levels of aromatose inhibitors like Letrozole or Arimidex, which means they are not bound to be as effective when used with nolvadex in the post cycle therapy. If you still go with these aromatose inhibitors you are wasting your money as Nolvadex has already reduced their effectiveness. Aromasin however remains unaffected by Nolvadex in this respect and should be considered as the aromatose inhibitor of choice. The reason Aromasin remains largely unaffected is because it is a type-I aromatose inhibitor meaning that once it has completed its job of deactivating the aromatase enzyme, you would not need it anymore. However, other aromatose inhibitors like Letrozole need to be present in the body for long periods of time which allows Nolvadex to intervene and alter their pharmacokinetics resulting in them losing their effectiveness.

Also, during Post cycle theraphy, Aaromasin cut down the production of Sex hormone Binding Globulin(SHBG) by at least 20% in males. SHBG is a notorious enzyme which attaches itself to testosterone and is known to render it useless for the purpose of body building. Other aromatose inhibitors do not have the potential to reduce SHBG.

The recommended and optimum usage of Aromasin is about a single dose of 50mg per day. After meals though, taking a single dose of 25mg can be potent enough to reduce the estrogen levels in the body by a dramatic 70-80% within 24 hours of consumption. Aromasin is not suitable for pregnant women and those who are lactating, children, those allergic to Aromasin or its other components, those being treated for prostrate of testicular cancer, high blood pressure patients and those having a history of stroke occurrence or liver damage etc.

Turinabol in bodybuilding

Oral Turinabol is actually a version of Methandrostenolone with extra chlorine atom in the fourth position. Hence the official name of Turinabol is  4-chloro-alpha-Dihydromethyltestosteron. This upgrade has made the drug practically non-aromatized. Even more, Turinabol metabolites very quickly leave the body, making huge advantage against the threat of doping tests. Like the vast majority of oral AAS oral Turinabol is 17-alpha alkylated, thus is potentially harmful to the liver. However, negative impact on the liver was not reported even after prolonged use. Oral Turinabol sufficiently resembles Methandrostenolone not only on the structure of the molecule but the action of both drugs is also very similar. Turinabol produces less gains, but this is “quality”, lean mass and also it produces less side effects. Despite Turinabol does not aromatize and is quite mild drug, prolonged usage may cause the suppression of secretion of endogenous testosterone but at much lesser extent comparing to Methandrostenolone (Dianabol) and it’s easily rejuvenated.

The difference between oral and injectable Turinabol is like with most of other steroids. Oral is easier to take but in theory it may be harmful to the liver, so one can sustain higher dosages of injectable version. Furthermore, injectable is slightly more detected. But, in general, this is a matter of personal preferences.

In bodybuilding Turinabol can be called a rookie. Not surprising – in the past “pharmacological king” in Eastern Europe used to be relatively cheap Methandrostenolone (Dianabol). All Turinabol smuggled from Eastern Germany was captured by light athletics coaches. Western Europe and USA even did not know that such product exists, at least no bodybuilders reported they ever used it. At-first Turinabol notably raises power. Secondly, as has been said, oral turinabol quickly leaves the body and not found in the urine within 6-8 days after end of usage. We have not heard about any positive doping tests for Turinabol. However, it may be because such tests are simply not being made nowadays. A positive feature of the drug can be considered as giving hardness to the muscles without any significant accumulation of water. Experience shows that using of Turinabol is almost mandatory in contest preparation stacks. Also it copes with the task of protection of muscle mass against destruction after bulking cycles.

Turanabol is mostly used to build  lean body mass and strength without water retention, which often occurs with Dianabol and testosterone. The results with Turanabol straightly depends on the daily dosage, which normally varies between 20 to 100 mg. Athletes below 90 kgs experience no side effects at 20 mg daily and more heavy athletes easily adopt 40 – 50 mg daily.

When administered 50 mg / ED it significantly increases dry muscle mass, strength, and all of this without water retention, which can cause serious side effects due to estrogen activity. Because of these characteristics, Turanabol is very effective product for power lifters. In order to increase the results at the end of the course it is recommended to combine this drug with Parabolan (200 mg every week) or with Stanozolol (150 mg every week). This is very good pre-competition combo as well. The above combination allows us to construct a relief and build muscle without any additional fat-burners and guaranteed against side effects such as gynecomastia and excessive estrogen.

In light athletics dosage is following: body weight in pounds divided by 10. For bodybuilders dosage is: body weight in kilograms divided by 1.5-2 (normally it’s 1.5 times more than your daily Dianabol dosage).

The Benefits of Anavar

Anavar was developed to manage conditions of muscle wasting and quick weight loss, as is a common reason for inception with any anabolic steroid. Developed in 1964, by Searle Laboratories to treat such conditions, Searle is no longer in existence as it was bought and absorbed into Pfizer in 2003.  As you can see Searle developed some very significant products over the years and its development of Anavar is no exception because with its inception one of the safest anabolic steroids for both men and women would hit the shelves.

Comprised of Oxandrolone, Anavar as it is commonly known is a Dihydrotestosterone (DHT) anabolic steroid with almost no androgenic qualities and peaceful anabolic properties. An oral steroid, Anavar is like most oral steroids a C17alpha-alkylated medication (17-aa) signification it has been altered at the 17th carbon position to allow it to survive ingestion by surviving the first pass through the liver; without the 17-aa alteration the steroid would be destroyed before it ever entered the blood stream. By this alteration the steroid is allowed to survive and enter the blood stream where it becomes active and the benefits are received. As you may grasp the 17-aa procedure can be toxic to the liver, for this reason many individuals will avoid oral anabolic steroids but as it pertains to Anavar we must build an exception. Unlike most 17-aa medications Anavar appears to be very mild on the liver, so mild that most who use it experience little to no elevation in liver enzymes.

As a very mild anabolic steroid Anavar is not well-suited for bulking cycles or gaining phases; you will not produce a vast amount of lean muscle tissue through its use when speaking of execution enhancing purposes; however, what is produced will be solid muscle tissue. The greatest benefits associated with this particular steroid lie within muscle preservation and metabolic activity. This simply means Anavar has the ability to not only aid in reducing corpse-fat but preserving muscle tissue while on a calorie restricted diet; further, the more muscle tissue we have the greater our metabolic activity will be thereby increasing the rate in-which corpse-fat is utilized for energy. Because Anavar is apt for fat reduction and muscle preservation it is commonly used by build athletes during their competition preparation, as well as by common gym rats who simply want to look leaner and tighter at the beach.

The Side-Effects of Anavar:
Most anabolic steroids carry with them the possibility of many adverse side-effects. It is significant to keep in mind these side-effects are only possible, they are by no means guaranteed or assured and are largely avoidable when used responsibly. However, negative side-effects can occur when steroids are abused and even in some who are sensitive even though they use responsibly they may fall prey to negative outcomes; the same can be said of Aspirin. While many anabolic steroids carry vast possible negative side-effects such as estrogenic related due to aromatization, Anavar does not possess these traits. Anavar does not aromatize making common side-effects such as Gynecomastia little to no concern; Further, as most steroids are very suppressive to normal testosterone production Anavar is very peaceful in this regard, so peaceful that one could take Anavar and still make some natural testosterone. However, some suppression will still exist and the extent will largely be portion dependent.